Wednesday April 14, 2010
Endovascular versus Open Repair of Abdominal Aortic Aneurysm

Background: Few data are available on the long-term outcome of endovascular repair of abdominal aortic aneurysm as compared with open repair.

Methods: From 1999 through 2004 at 37 hospitals in the United Kingdom, we randomly assigned 1252 patients with large abdominal aortic aneurysms (5.5 cm in diameter) to undergo either endovascular or open repair; 626 patients were assigned to each group. Patients were followed for rates of death, graft-related complications, reinterventions, and resource use until the end of 2009.

Results

• The 30-day operative mortality was 1.8% in the endovascular-repair group and 4.3% in the open-repair group (P=0.02).
• The endovascular-repair group had an early benefit with respect to aneurysm-related mortality, but the benefit was lost by the end of the study, at least partially because of fatal endograft ruptures (P=0.73).
• By the end of follow-up, there was no significant difference between the two groups in the rate of death from any cause (P=0.72).
• The rates of graft-related complications and reinterventions were higher with endovascular repair, and new complications occurred up to 8 years after randomization, contributing to higher overall costs.

Conclusions: In this large, randomized trial, endovascular repair of abdominal aortic aneurysm was associated with a significantly lower operative mortality than open surgical repair. However, no differences were seen in total mortality or aneurysm-related mortality in the long term. Endovascular repair was associated with increased rates of graft-related complications and reinterventions and was more costly.


Endovascular versus Open Repair of Abdominal Aortic Aneurysm - Published at www.nejm.org April 11, 2010